vt.

1. 使疏远；使感情失和[（+from）]
   His foolish behavior estranged all his friends.

   他的愚蠢行为令所有的朋友与之疏远。

   The argument estranged him from his wife.

   这一争论使他同妻子疏远了。

v.

1. cause to feel less close or friendly; alienate.
2. [as adj. estranged] (of a husband or wife) no longer living with their spouse.